Abstract
Background Previous studies investigated the risk of suicide in patients with Parkinson's disease (PD) but reported discrepant results. Deep brain stimulation (DBS) is an effective therapy for PD, while its effect on suicide risk has seldom been researched. This meta-analysis aimed to estimate the risk of suicide and/or suicidal ideation in PD patients and in PD patients who underwent DBS. Methods Relevant articles published in the PubMed or EMBASE or CNKI database from 1990 to December 2019 were sourced, and the combined standardized mortality rate (SMR) or odds ratio (OR) was pooled. Result A total of 1070 articles were found. After screening, 4 cross-sectional studies, 4 cohort studies, 2 randomized controlled trial studies, and 2 case-control studies were included in this meta-analysis. Pooled data indicated that PD patients may have increased risk of suicide (lnSMR, 0.459; 95% confidence interval (CI), 0.286 to 0.632; p < 0.001). No significant difference was found in the risk of suicide when comparing PD patients who underwent DBS with PD patients who received only drug therapy (OR = 2.844, 95%CI: 0.619 to 13.072, p=0.179). DBS may increase the risk of suicide and/or suicidal ideation in PD patients compared with general population (lnSMR = 3.383, 95%CI: 2.839 to 3.927, p < 0.001). Conclusion PD patients have higher risk of suicide and/or suicidal ideation compared with controls, while PD patients who received DBS tend to have an increased risk of suicide or suicidal ideation. Psychological evaluation is needed in PD patients, and pre- and post-operation evaluations are necessary for PD patients who underwent DBS.
Highlights
Parkinson’s disease (PD) is the second most common neurodegenerative disorder that affects 2–3% of the population ≥65 years of age [1]
Many risk factors other than depression have been identified contributing to suicide and/or suicidal ideation in PD patients, including non-motor symptoms, motor complications, and the increased disability [1], and our understanding of suicidality in PD patients is still limited [5]. e specific prevalence rate of suicide and/or suicidal ideation in PD patients varies between studies, and some studies even found that the prevalence of suicide in PD patients was lower than that in general population [6]
Studies comparing PD patients who underwent Deep brain stimulation (DBS) with general population presented a significant publication bias (z 16.290, p < 0.001). This meta-analysis identified a decreased risk of suicide and/or suicidal ideation in PD patients compared with general population
Summary
Parkinson’s disease (PD) is the second most common neurodegenerative disorder that affects 2–3% of the population ≥65 years of age [1]. Many risk factors other than depression have been identified contributing to suicide and/or suicidal ideation in PD patients, including non-motor symptoms, motor complications, and the increased disability [1], and our understanding of suicidality in PD patients is still limited [5]. Limited studies have shown that DBS treatment may increase the rate of suicide in PD patients [9,10,11]. Erefore, Parkinson’s Disease the risk of suicide in PD patients who underwent DBS treatment should be noticed in clinic, and it is helpful to verify the specific prevalence of suicide and/or suicidal ideation in PD patients who underwent DBS. Previous studies investigated the risk of suicide in patients with Parkinson’s disease (PD) but reported discrepant results. Deep brain stimulation (DBS) is an effective therapy for PD, while its effect on suicide risk has seldom been researched
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