Abstract

With recent advances in research on the genetics of Parkinson disease, molecular classification is increasingly possible. However, understanding the phenotypes of different parkinsonian syndromes and knowing when to test for various mutations are becoming more challenging. Originally, parkin gene mutations were identified as a cause of autosomal-recessive juvenile parkinsonism, but they also have been found in sporadic cases, particularly early-onset cases. Two research groups now report further details about the frequency of these mutations. To estimate …

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