Comparative analysis of event-related potentials and oscillations during auditory oddball task in parkinson?s patients with parkin gene mutations and idiopathic parkinson?s disease

Abstract

Event Abstract Back to Event Comparative analysis of event-related potentials and oscillations during auditory oddball task in parkinson’s patients with parkin gene mutations and idiopathic parkinson’s disease Atilla Uslu1*, Mehmet Ergen2, Hasan Demirci1, Hasmet Hanagasi1 and Tamer Demiralp1 1 Istanbul University, Istanbul Faculty of Medicine,, Turkey 2 Acibadem University, Faculty of Medicine, Turkey Parkinson’s disease (PD) is characterized by motor impairment, but clinical evidence suggests that PD patients develop deficits across many cognitive functions. Parkin (PARK2) gene mutations are most common cause of the autosomal recessive form of PD. We aimed to compare the cognitive decline of patients with parkin gene mutation and idiopathic PD patients by event-related potentials (ERPs) and event related oscillations (EROs) during auditory oddball task. Experiments were carried out on the following four groups of subjects: control (n = 25), Parkin mutation (PM-PD, n = 15), early onset (EO-PD, n = 25) and late onset (LO-PD, n = 25) idiopathic PD. Both P3 amplitudes and evoked delta (2-4 Hz, 100-400 ms) power of the target condition were significantly reduced in EO-PD and LO-PD groups compared with the controls, while no significant difference was observed for the PM-PD group. However, both total delta (2-4 Hz, 100-400 ms) and total theta (5-12 Hz 50-250 ms) powers in target responses were significantly reduced in all three PD groups. While the absence of significant ERP changes in PM-PD group is in-line with the literature that reports relatively lighter cognitive decline in relatively younger PM-PD patients, the in-depth time-frequency analysis of the brain electrical responses shows that a significant change can be observed in terms of induced (non-phase-locked) EROs. This can be a starting point for understanding the neural mechanisms that are affected in this subgroup of Parkinson's patients. Keywords: brain oscillations, Parkison Conference: XI International Conference on Cognitive Neuroscience (ICON XI), Palma, Mallorca, Spain, 25 Sep - 29 Sep, 2011. Presentation Type: Poster Presentation Topic: Poster Sessions: Quantitative Analysis of EEG, MEG & Brain Oscillations Citation: Uslu A, Ergen M, Demirci H, Hanagasi H and Demiralp T (2011). Comparative analysis of event-related potentials and oscillations during auditory oddball task in parkinson’s patients with parkin gene mutations and idiopathic parkinson’s disease. Conference Abstract: XI International Conference on Cognitive Neuroscience (ICON XI). doi: 10.3389/conf.fnhum.2011.207.00147 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 17 Nov 2011; Published Online: 28 Nov 2011. * Correspondence: Dr. Atilla Uslu, Istanbul University, Istanbul Faculty of Medicine,, Isntabul, Turkey, atillauslu_itf@hotmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Atilla Uslu Mehmet Ergen Hasan Demirci Hasmet Hanagasi Tamer Demiralp Google Atilla Uslu Mehmet Ergen Hasan Demirci Hasmet Hanagasi Tamer Demiralp Google Scholar Atilla Uslu Mehmet Ergen Hasan Demirci Hasmet Hanagasi Tamer Demiralp PubMed Atilla Uslu Mehmet Ergen Hasan Demirci Hasmet Hanagasi Tamer Demiralp Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.