Abstract
INTRODUCTION Although Parkinson’s disease (PD) primarily affects the central nervous system, it is a multi-organ disease which also affects the eyes and the peripheral nervous system, including the autonomic fibers (,). PD-related disturbance of the peripheral nerves may result in sensory, motor, or autonomic neuropathy. Autonomic dysfunction can manifest as sicca syndrome, hypo-/hyperhidrosis, orthostatic hypotension, reduced blood pressure variability, reduced heart rate variability, nausea, constipation, vomiting, urinary dysfunction, or erectile dysfunction (). Non-motor manifestations, such as hyposmia, rapid eye movement [...]
Highlights
Parkinson’s disease (PD) primarily affects the central nervous system, it is a multi-organ disease which affects the eyes and the peripheral nervous system, including the autonomic fibers [1,2]
PD-related disturbance of the peripheral nerves may result in sensory, motor, or autonomic neuropathy
PD-related neuropathy (PDRNP) is well recognized, relatively little data about this topic are available. This mini-review aimed to summarize and discuss previous and current data to provide an overview of the clinical presentation, diagnosis, frequency, and therapeutic management of PDRNP
Summary
Parkinson’s disease (PD) primarily affects the central nervous system, it is a multi-organ disease which affects the eyes and the peripheral nervous system, including the autonomic fibers [1,2]. Autonomic dysfunction can manifest as sicca syndrome, hypo-/hyperhidrosis, orthostatic hypotension, reduced blood pressure variability, reduced heart rate variability, nausea, constipation, vomiting, urinary dysfunction, or erectile dysfunction [1]. Non-motor manifestations, such as hyposmia, rapid eye movement sleep behavior disorder (RBD), constipation, or depression, may precede these motor symptoms [1]. PD-related neuropathy (PDRNP) is well recognized, relatively little data about this topic are available. This mini-review aimed to summarize and discuss previous and current data to provide an overview of the clinical presentation, diagnosis, frequency, and therapeutic management of PDRNP
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