Abstract
This chapter provides an overview of the pathogenic mechanisms of parietal cell autoantibodies and characterizes antigenic and biological properties of these autoantibodies. Parietal cell autoantibodies are associated with autoimmune gastritis and pernicious . These autoantibodies recognize α- and β-subunit of the gastric H/K adenosine triphosphatase (ATPase), a highly specialized proton pump located in the unique intracellular membranes of gastric parietal cells. The identification of the target autoantigens provides an explanation for the cell specificity of these autoantibodies. These autoantibodies are involved in the pathogenicity of disease and are produced as a secondary consequence of a cell-mediated autoimmune response to the gastric mucosa. The presence of these autoantibodies provides a convenient diagnostic probe for type A chronic atrophic gastritis.
Published Version
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