Abstract
Pareto-Optimal Operating Policies of a Three-Phase- Fluidized-Bed Reactor Used for the Oxidation of D-Glucose on Co-Immobilized Pyranose Oxidase and Catalase
Highlights
When developing an industrial enzymatic process, one essential engineering problem concerns the choice of the reactor optimal operating policy based on à-priori knowledge of the process kinetics and enzyme inactivation characteristics
An elegant option developed in this paper is to obtain sets of Pareto optimal solutions, called Pareto-optimal fronts, each one generated for the case of at least two adverse objectives
Exemplification is made for the case of the oxidation of D-glucose (DG) to 2-keto-Dglucose in the presence of P2Ox and catalase, continuously operated in a three-phase-fluidizedbed reactor (TPFB) with co-immobilized enzymes on alginate beads (Figure 1)
Summary
When developing an industrial enzymatic process, one essential engineering problem concerns the choice of the reactor optimal operating policy based on à-priori knowledge of the process kinetics and enzyme inactivation characteristics. For a multi-enzymatic system, involving complex interactions among enzymes that exhibit optimal activity on different parametric domains, and a high-order deactivation, this problem requires an extended analysis. The engineering problem becomes difficult when a multi-objective optimization problem is formulated.
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