Abstract
Methods A birth cohort in southern Taiwan was studied. Information about parental allergic histories, gender, prematurity, TSE, and childhood allergic disease ever diagnosed by a physician were acquired from questionnaire during follow up. Children were asked to follow up at 6 years of age for allergic questionnaire and sensitization examination (CAP system). Results In this cohort study, 748 of the children with complete data were analyzed. 217 (29%) of children had positive parental allergic history, 191 (25.5%) of children had TSE history, and 186 (24.9%) of children had been diagnosed as asthma by a physician in the first 6 years of life. In a regression analysis, physician diagnosed asthma ever in the first 6 years of life were significantly associated with male gender (OR: 1.941, 95% CI: 1.371-2.748, p 0.5). Besides, TSE and parental allergic history had synergistic influence on the physician diagnosed asthma ever in the 6 years of life. This synergistic influence was significant in girls, rather than in boys (Table 1).
Highlights
Genetic inheritance and perinatal tobacco smoke exposure (TSE) have been proven to be critical for the development of childhood allergic diseases [1, 2]
This study investigated the interactive roles of parental allergic histories and TSE on the development of childhood asthma at 6 years old
TSE and parental allergic history had synergistic influence on the physician diagnosed asthma ever in the 6 years of life. This synergistic influence was significant in girls, rather than in boys (Table 1)
Summary
Chih-Chiang Wu1,2,3, Te-Yao Hsu4*, Ho-Chang Kuo, Chia-Yu Ou4, Jen-Chieh Chang, Chieh-An Liu, Chih-Lu Wang, Hua Chuang, Hsiu-Mei Liang, Kuender D Yang2,3,9*. From Canadian Society of Allergy and Clinical Immunology Annual Scientific Meeting 2013 Toronto, Canada. From Canadian Society of Allergy and Clinical Immunology Annual Scientific Meeting 2013 Toronto, Canada. 3-6 October 2013
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