Abstract
Two important problems in the pathogenesis of "parenchymatous nephritis" are (1) the cause of the albuminuria and (2) the cause of the edema. The latter problem at least is concerned with an alteration in the equilibrium between the cells and body fluids; the most promising methods of handling such a problem are physicochemical. The present paper deals with the results obtained by applying one such method, namely, the determination of surface tension. Substances lowering surface tension have already been found in nephritic urine. It is known that substances which lower the surface tension at a phase boundary accumulate in greater concentration at such a boundary; and it is reasonable to suppose that at the interface, changes in permeability would result. In the present paper it will be shown that a marked lowering of the surface tension of the blood serum occurs in parenchymatous nephritis; in another paper, it will be
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