Abstract
This study was supported by the Gaziosmanpasa University (project no: 2015/28). The authors would like to thank the patients and the controls for their participation
Highlights
Mood disorders are thought to be caused by a combination of environmental, psychological, biological and genetic factors
The present study examined the L55M and Q192R polymorphisms of paraoxonase 1 (PON1) gene in patients with depression and bipolar disorder
We did not find any association between the L55M and Q192R polymorphisms and major depression and bipolar disorder
Summary
Mood disorders are thought to be caused by a combination of environmental, psychological, biological and genetic factors. It was shown that oxidative and nitrosative stress pathways, along with immune-inflammatory response, might play an important role in the pathogenic mechanisms underlying major depression and bipolar disorder[1]. Studies concerning the relationship between PON1 polymorphism and mood disorders exhibited inconsistent results. Oxidative and nitrosative stress pathways, along with immune-inflammatory response, might play an important role in the pathogenic mechanisms underlying major depression and bipolar disorder. Objective: The aim of the present study is to investigate paraoxonase 1 polymorphisms and its correlations with disease parameters in patients with major depression and bipolar affective disorder. Discussion: Evaluating the different stages of patients with affective disorders and and investigating the connection between PON1 polymorphisms and treatment outcomes will help us to clarify the relationship between PON1 and mood disorders
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