Abstract
Many studies have examined the association between paraoxonase 1 (PON1) -L55M polymorphisms and risk of coronary heart disease (CHD), but the results remained inconsistent. We therefore aimed to address this association by performing an updated meta-analysis in the Chinese population. The PubMed, EMBASE, Web of Science, and Chinese National Knowledge Infrastructure were searched up to May 2020. The strength of statistical association was assessed with odds ratio (OR) and 95% confidence interval (CI). A total of eight studies with 1826 CHD cases and 1817 controls were finally included in the analysis. In the overall and subgroup analyses by control sources and geographic areas, the results showed no significant associations with CHD among all analysis models. Furthermore, we performed the analysis by including or excluding the HWE-violating studies. The results suggested that the MM genetype were significantly associated with CHD in studies not consistent with HWE under recessive and dominant models. This meta-analysis demonstrates that the PON1 -L55M polymorphism may not be associated with CHD risk in the Chinese population. Further studies with strict selection of patients and controls in different ethnic populations will be required to clarify this finding.
Highlights
Coronary heart disease (CHD), one of the major causes of morbidity and mortality worldwide, had become a growing public health problem in developing or lower-income countries (Teo & Dokainish, 2017)
In order to reduce the influence of the diverse backgrounds, we performed a meta-analysis to assess the relationship between Paraoxonase 1 (PON1) -L55M polymorphism and CHD risk in the Chinese population
Seventy-nine articles which examined the association between PON1 -L55M polymorphisms and CHD were identified
Summary
Coronary heart disease (CHD), one of the major causes of morbidity and mortality worldwide, had become a growing public health problem in developing or lower-income countries (Teo & Dokainish, 2017). Despite advances in our understanding of cardiovascular disease, detailed pathogenetic mechanisms of CHD are not fully understood. Paraoxonase 1 (PON1) -L55M (rs854560) has been identified as one of single nucleotide polymorphisms contributing to the CHD susceptibility. Individual studies with small sample sizes that are known to have low statistical power and yielded poor replication record. This lack of reproducibility might stem from racial or regional differences and discrepant lifestyle backgrounds. In order to reduce the influence of the diverse backgrounds, we performed a meta-analysis to assess the relationship between PON1 -L55M polymorphism and CHD risk in the Chinese population
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
