Abstract
BackgroundAmong human neoplasms thymomas are associated with highest frequency with paraneoplastic autoimmune diseases.Case presentationA case of a 42-year-old woman with paraneoplastic pemphigus as the first manifestation of thymoma is reported. Transsternal complete thymoma resection achieved pemphigus regression. The clinical correlations between pemphigus and thymoma are presented.ConclusionOur case report provides further evidence for the important role of autoantibodies in the pathogenesis of paraneoplastic skin diseases in thymoma patients. It also documents the improvement of the associated pemphigus after radical treatment of the thymoma.
Highlights
Paraneoplastic pemphigus is rarely associated with thymic neoplasms either alone or concomitantly with other autoimmune disorders
The pathogenetic and clinical relationships between pemphigus and thymoma encountered in this case are presented with the purpose of strengthening the hypothesis that pemphigus in the presence of a thymoma could be a thymoma-associated autoimmune disease
The clinical diagnosis of pemphigus vulgaris was confirmed by biopsy
Summary
Our case report provides further evidence for the important role of autoantibodies in the pathogenesis of paraneoplastic skin diseases in thymoma patients. It documents the improvement of the associated pemphigus after radical treatment of the thymoma
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