Abstract
Skin manifestations of systemic disease and malignancy are extremely polymorphous. Clinicians should be familiarized with paraneoplastic dermatoses in order to perform an early diagnosis of the underlying neoplasm. Lack of familiarity with cutaneous clues of internal malignancy may delay diagnosis and treatment of cancer. In this review, we described several paraneoplastic dermatoses and discussed extensively two paradigmatic ones, namely paraneoplastic pemphigus and paraneoplastic dermatomyositis.
Highlights
Paraneoplastic dermatoses (PD) are heterogeneous, rare, acquired diseases characterized by the presence of an underlying neoplasia
The neoplasm is detected before the onset of paraneoplastic pemphigus (PNP), but in about 30% of cases, the skin manifestations lead to the detection of an occult neoplasia [7,11]
PNP cases associated with benign tumors, such as localized Castleman disease and benign thymoma, usually improve or achieve a complete remission after tumour resection [7,9]
Summary
Paraneoplastic dermatoses (PD) are heterogeneous, rare, acquired diseases characterized by the presence of an underlying neoplasia. Up to 25% of the patients affected by ANM show tripe palms (TP), known as acquired pachydermatoglyphia, and florid cutaneous papillomatosis (FCP) [1,3] It may be associated with the sudden onset of multiple seborrheic keratosis (Leser–Trélat syndrome) [1,3]. The neoplasm is detected before the onset of PNP, but in about 30% of cases, the skin manifestations lead to the detection of an occult neoplasia [7,11]. PNP cases associated with benign tumors, such as localized Castleman disease and benign thymoma, usually improve or achieve a complete remission after tumour resection [7,9]. Several other skin manifestations have been reported, including non-specific and rare skin features [49,50]
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