Abstract
Dose-response studies with des-(pyro) Glu-LH-RH, [Phe 3] LH-RH, [Phe 5] LH-RH [0-methyl-Tyr 5] LH-RH, [Ile 7] LH-RH and des-Gly 10-LH-RH-ethylamide show concomitant stimulation of adenohypophyseal adenosine 3',5'-monophosphate (cyclic AMP) concentration, and LH and FSH release in rat anterior pituitary gland in vitro. Des-His 2-des-Gly 10-LH-RH-ethylamide, and inhibitor of the response to LH-RH in vivo, had no effect on cyclic AMP accumulation or on LH release in vitro. The present finding of parallel changes of intracellular cyclic AMP levels and hormonal release with LH-RH analogs having a wide spectrum of biological activity adds strong support for a role of the cyclic nucleotide as mediator of the action of LH-RH in the anterior pituitary gland.
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