Abstract
BackgroundLess than 80 reported cases of paragangliomas of the larynx are reported in the literature. A role for external beam radiation in this disease has not yet been explored. We present four cases of laryngeal paragangliomas treated at a large tertiary-care cancer center over a 35-year period.Methods124 cases of head and neck paragangliomas treated at a single institution from 1970 to 2005 were retrospectively studied. Patients with laryngeal paragangliomas were identified, and a comprehensive clinico-pathological review was undertaken.ResultsWe identified 4 patients with tumors arising in the larynx at the following subsites: supraglottis (2), glottis (1), and subglottis (1). Three patients were treated with surgery and one with definitive radiation alone.ConclusionsLaryngeal paragangliomas are rare tumors and are adequately treated with surgical resection. We also present one patient who was treated with radiation and had disease stabilization. Accurate histological classification is critical, and the role of genetic testing is emerging.
Highlights
Paragangliomas of the laryngopharynx are rare tumors that are of neuroendocrine origin and arise from the neural crest-derived cells of the parasympathetic nervous system
Since its first description in the literature in 1955, fewer than 80 such cases have been reported [1]. These benign lesions have a clinical course marked by slow growth, with symptoms often mimicking those of a squamous cell carcinoma
We reviewed a single-institutional experience with laryngeal paragangliomas treated over a 35-year period
Summary
Laryngeal paragangliomas are rare tumors and are adequately treated with surgical resection. Accurate histological classification is critical, and the role of genetic testing is emerging
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