Abstract
Background: This study aims to conduct a 10-year follow-up to assess ASCVD risk in Pakistan among individuals aged 30 years and above without a known history of ASCVD. The focus will be on evaluating ASCVD risk over this specific 10-year timeframe. The study will also validate risk assessment scores for identifying high-risk individuals and examine the incidence rate of ASCVD events during long-term follow-up. Methodology: In this prospective cohort study, ASCVD risk in adults will be assessed by selecting participants aged 30 and above through a non-probability convenient sampling technique. The sample size of 3,513 will be stratified across Pakistan's provinces. Alongside demographics and clinical history, the study will calculate 10-year, 30-year, and lifetime ASCVD risks, incorporating genetic assessment for Apo B. Personalized management recommendations based on ASCVD risk will be provided, and a six-month follow-up will track ASCVD events. The data analysis will employ descriptive statistics and subgroup analysis for comprehensive insights. Discussion: Given the rising ASCVD prevalence, this study is crucial for understanding disease patterns and identifying high-risk individuals among adults aged 30 and above in Pakistan. It contributes valuable information to the knowledge base on ASCVD, guiding preventive measures for policymakers and healthcare professionals. The ultimate goal is to reduce ASCVD incidence, lessen the burden, and enhance cardiovascular health.
Published Version
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