Paracetamol versus Paracetamol Plus Ondansetron on Acute Postoperative Pain.

Mahnaz Narimani Zamanabadi,Giti Dehghanmanshadi,Sepideh Davoodinejad,Farshid Gholami,Kourosh Farazmehr,Mohamad Aryafar

doi:10.1055/s-0041-1735899

Mahnaz Narimani Zamanabadi, Giti Dehghanmanshadi + Show 4 more

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https://doi.org/10.1055/s-0041-1735899

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This study was performed to determine the comparative efficacy of paracetamol alone versus paracetamol plus ondansetron on acute postoperative pain after abdominal surgeries in Azad University hospitals in 2017 and 2019. In this randomized clinical trial, 62 consecutive patients under abdominal surgeries, were randomly divided into two groups, group 1 patient who received paracetamol alone 1 gram and group 2 patient who received paracetamol 1 gram plus 4 mg ondansetron and the pain severities were determined and compared between groups at recovery and after 4 and 24 hours. The results of this study revealed that there were no statistically significant differences between two groups for the postoperative pain severity and analgesic use ( p > 0.05). It may be concluded that addition of ondansetron to paracetamol would not result in further postoperative pain reduction and additive use of this drug is not recommended.

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Mohamad Aryafar, MD1 Mahnaz Narimani Zamanabadi, MD1 Kourosh Farazmehr, MD1 Giti Dehghanmanshadi, MD1 Sepideh Davoodinejad, MD2 Farshid Gholami, MD1
Long-term administration with high doses of analgesics may cause bleeding at the site of gastrointestinal bleeding and renal failure, and nonopioid analgesics do not have these complications.[15,16]
The distribution of age, gender, body mass index (BMI), American Society of Anesthesiologists (ASA) class, and type of surgery were identical in two groups (p-values were as follows: p 1⁄4 0.872, p 1⁄4 0.793, p 1⁄4 0.855, p 1⁄4 0.199, and p 1⁄4 0.316, respectively)

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Mohamad Aryafar, MD1 Mahnaz Narimani Zamanabadi, MD1 Kourosh Farazmehr, MD1 Giti Dehghanmanshadi, MD1 Sepideh Davoodinejad, MD2 Farshid Gholami, MD1. Pain is one of the problems that always harms the person and has many unwanted side effects. Long-term administration with high doses of analgesics may cause bleeding at the site of gastrointestinal bleeding and renal failure, and nonopioid analgesics do not have these complications.[15,16] in this study, we compared the effect of paracetamol alone or paracetamol plus endonestrone one on acute pain after abdominal surgery in hospitals of Islamic

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