Abstract
Paracetamol is accessible as a nonspecific medicine, with brand names counting Tylenol and Panadol among others. In 2019, it was the 145th most commonly prescribed medication in the world, with more than 4 million prescriptions. Therefore, the present study has been carried out to investigate the paracetamol toxicity on lipid peroxidation andd antioxidant enzymes in male New Zealand white rabbits. Animals were assigned to one of two treatment groups: 0 mg paracetamol kg BW [control]; 500 mg paracetamol/kg BW. Rabbits were orally managed the particular dosages each other day for 12 weeks. Results obtained showed that paracetamol significantly [P < 0.05] induced thiobarbituric acid-reactive substances [TBARS; the marker of lipid peroxidation] in plasma, while the activities of glutathione S-transferase [GST], superoxide dismutase [SOD] and catalase [CAT], and the level of sulfhydryl groups [SH-group] were decreased [P < 0.05] in blood plasma. Keywords: Paracetamol; TBARS; Glutathione S-Transferase; Rabbits
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