Papular-purpuric Gloves and Socks Syndrome in a 46-year-old Man with Mycoplasma pneumoniae Respiratory Disease

Abstract

Mycoplasma pneumoniae is a cause of upper and lower respiratory disease,
 predominantly in children and young. Dermatologic manifestations of the
 infection occur in 1-5% of the cases, most commonly as Stevens–Johnson Syndrome
 and Erythema Multiforme. We present a 46-year-old previously healthy man heavy
 smoker, who was admitted due to fatigue, chest pain, cough, and fever that
 appeared seven days earlier. He was diagnosed pleuro-pneumonia caused by Mycoplasma pneumoniae. Apart from
 bicytopenia as toxic extrapulmonary manifestation of the infection, he
 developed a relatively novel pruritic
 dermatosis - papular-purpuric gloves and socks syndrome (PPGSS). Under antibiotic treatment, disease had
 favorable outcome. In the cases of PPGSS without known etiologic agent, testing for Mycoplasma pneumoniae might be useful to
 reveal etiology of the syndrome, especially in adult subjects. Some of the known constitutional symptoms of PPGSS
 such as fever and fatigue, may also belong to the co-existing viral or
 bacterial infection.  J Microbiol Infect Dis 2018; 8(4):158-161