Abstract
Prior radiation exposure is the best known risk factor for thyroid cancers, and papillary thyroid carcinoma (PTC) may arise from dyshormonogenetic goiter. A 17-year-old female patient was admitted to the department of chest diseases with respiratory symptoms. The patient had undergone a thyroid surgery for goiter at the age of 9. A bilateral nodular opacity was detected by radiological examination. The histopathologic examination of the specimen obtained from computed tomography guided trucut biopsy was diagnosed as PTC. We present a very rare case of PTC with lung metastasis that had undergone subtotal thyroidectomy due to dyshormonogenetic goiter eight years ago.
Highlights
Thyroid cancers are the most common endocrine malign tumors
In the regions with insufficient iodine, follicular carcinoma is more common than papillary carcinoma
Malignant transformation may occur in the children with congenital hypothyroidism if the risk of thyroid nodule is increased by the presence of dyshormonogenesis or iodine transport defect
Summary
Thyroid cancers are the most common endocrine malign tumors. Papillary thyroid carcinoma (PTC) is the most frequent type with a ratio of 80% [1, 2]. The lungs and the bones are the most common sites for distant metastasis [3]. The two mechanisms are responsible for the development of dyshormonogenesis. These mechanisms are defects in synthesis and secretion of thyroglobulin and organification of iodine caused by TPO gene mutations [9]. The mechanisms are not known regarding thyroid cancer development from dyshormonogenetic goiter. It has been suggested that thyroid carcinoma may develop from dyshormonogenetic goiter due to long-term increased thyrotropin plasma levels [10]. We present a very rare case of PTC with lung metastasis that had undergone subtotal thyroidectomy due to dyshormonogenetic goiter eight years ago
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