Paperchromato法及びPagnotto法によるToluene作業者の尿中馬尿酸の排泄量について : Thinner中毒第7報, 有機溶剤中毒第11報

Abstract

In an automobile factory, the concentration of toluene in the air and the content of hippuric acid in the urine of workers working in a shop where toluene is used was estimated by paperchromatography and Pagnotto's. method. Workers, after spraying toluene dissolved in the paste on the ceiling of driver's seat pasted plastic board on it. Average toluene density acting on the worker was calculated from the toluene density at the driver's seat and the actual working time on that seat by time study. Average density at which the toluene was inhaled was also calculated from the urinary hippuric acid content by the use of the line indicating their relationship as reported before. The results obtained were as follows. 1) There was a tendency that the toluene density decreased as the room temperature dropped in winter. 2) Excretion of the urinary hippuric acid taken at midday was more than that at the beginning of the work, and at the maximum at the end of the work. 3) Toluene density as well as urinary hippuric acid content in this shop decreased in 1965 compared to those in 1964, because air conditioning apparatus had been set at the beginning of 1965. 4) Toluene density to which workers were exposed was in accordance with the inhaled toluene density calculated from the urinary hippuric acid of workers. 5) A high correlation between urinary hippuric acid concentrations obtained by Ogata and Nagao's DAB method and Pagnotto's method seen at the level over 1 mg/ml of H.A.