Abstract
Changes in protein levels after thyroidectomy or in hypothyroidism have been reported by several authors. For these studies, different procedures have been used, such as: salting out, free electrophoresis (Levin & Leathem, 1942; Moore, Levin & Smelser, 1945; Lewis & McCullagh, 1944) and zone electrophoresis (Lamberg & Gräsbeck, 1955; Boas, 1955). In a previous report from this laboratory, a significant hypoproteinemia was observed in thyroidectomized rats compared with normal controls (Abreu et al., 1956). This was also found in thyroidectomized dogs (Podhraszky, 1942 a, b). In the previous experiments (Abreu et al., 1956), total serum protein-bound carbohydrates (determined as galactose-mannose) was lowered in the operated animals, this being interpreted as a consequence of the hypoproteinemia. On the other hand, Boas (1955), reported increased plasma hexosamine concentrations after thyroidectomy and these changes were explained as being due to an increase in the amino sugar content of the β- and γ-globulin fractions.
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