Abstract
Hypothesis: The suprascapular nerve is prone to traumatic injury during falls on an out-stretched hand, as well as secondary to blunt trauma to the top of the shoulder, due to its relatively fixed position under the ligaments and rotator cuff as well as high position on the brachial plexus. The supraspinatus muscle is innervated by the suprascapular nerve and routinely undergoes fatty degeneration and fibrosis with rotator cuff pathology in a manner that grossly seems analgous to a nerve injury. Although the supraspinatus is also the most studied muscle of rotator cuff, the pathophysiology of motor endplate degeneration specific to humans is not well understood. Patients with traumatic peripheral nerve injuries provide a unique opportunity to capture this invaluable data about human muscle degeneration.We hypothesized that the time course of human motor endplate degeneration after traumatic nerve injury is temporally correlated with the duration of denervation after traumatic nerve injury. We tested this hypothesis by rigorously analyzing denervated human muscle tissue to build a temporal profile of neuromuscular junction (NMJ) degeneration after a distinct, identifiable injury so as to better understand end stage human muscle degeneration.
Published Version
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