Abstract
1. 1. This pilot study examined physiological concomitants of lactate-precipitated panic in six patients selected according to DSM-III criteria for panic disorder. 2. 2. Electrophysiological measures of central, autonomic and skeletal-muscular activities were monitored during a baseline period, i.v. administration of 5% D/W and of 0.5 M sodium lactate. 3. 3. Panic episodes were elicited in all patients following lactate administration. Marked increases in HR, EOG and EMG together with EEG alpha reduction, P 2-N 2 amplitude reductions of the AEP and paradoxical increases in EEG delta activity indicate that experimentally induced panic states are characterised by physiological hyperarousal.
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