Panel Discussion II: Usefulness of in vitro and in vivo Model Systems for Predicting the Adverse Public Health Outcome for Antimicrobial Drug Residues in Food

Abstract

Dr. Beaulieu: We asked the panelists to spend about ten minutes each, addressing two questions. The first question is which in vitro and in vivo models or methods should be considered to evaluate the public health risk associated with antimicrobial residues in food, and can the model or method be used to evaluate more than one microbiological or functional endpoint in one test? The second question is how should the results obtained be used to establish an ADI? Is the standard toxicology formula appropriate to calculate an ADI for antimicrobial residues?