Abstract
Parallel determinations of values for volume of duodenal contents and for bicarbonate, amylase, trypsin and lipase in the duodenal contents have been made in man after stimulation with Vitamin A administered intramuscularly, cooked starch, casein and olive oil administered intraduodenally, prostigmine methylsulfate and mecholyl chloride administered subcutaneously, secretin administered intravenously and secretin and mecholyl chloride injected in combination. Vitamin A and starch did not produce a measurable stimulation of the fractions of duodenal contents. Mecholyl chloride appeared to stimulate the various fractions of duodenal contents more uniformly than, and as potently as did casein, fat and prostigmine methylsulfate and for this reason appeared to be preferable to foods and prostigmine methylsulfate as a stimulant.
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