Effect of MK-329 on Pancreatic Secretion in Man

Abstract

The relative importance of hormonal and neural factors in the regulation of pancreatic exocrine secretion in man has been much debated. Circulating cholecystokinin (CCK) is generally regarded as an important stimulant of the postprandial pancreatic enzyme output based on studies where the enzyme response to physiological doses of exogenous CCK have been compared to the food stimulated response [1,2]. Most of these studies have concluded that postprandial elevations in plasma CCK concentrations are sufficient to produce the pancreatic enzyme secretion normally occurring after a meal. However, such evidence does not prove conclusively that CCK is the sole, or major, physiologic regulator of pancreatic enzyme secretion compared to other hormonal or neural factors.