Abstract
We aimed to estimate the incidence and to assess the risks factors associated with pancreatic cancer (PC) in people with HIV (PWH). We used electronic medical record data from 2009 to 2020 available in the COREVIH Ile-de-France Est database of PWH treated in Paris' public hospitals. We analyzed data on patient demographics, treatment history, and immuno-virologic status. A case-control study was designed, each case (PWH and PC) was matched on age, gender and duration of HIV infection to four controls (PWH without PC). Twenty-four cases were identified from the database, with an incidence of PC estimated at 28 cases (95%CI [19-43]) per 100,000 persons-year. The median age was 57 years (IQR [51-68]) at cancer diagnosis. Twenty-one cases were male (88%). Median CD4+ T cell count at PC diagnosis was 587/mm3 (IQR [317-748]) and the nadir CD4+ T cell count was 194 (IQR [98-380]). Twenty cases (91%) had a suppressed HIV replication at PC diagnosis. Twelve patients (50%) had metastasis on diagnosis. Median time to death after cancer diagnosis was 11 months [IQR 1-19]. Twenty-two cases were matched with 88 controls. There was no statistically significant risk factors for PC identified in our analysis. Pancreatic cancer remains rare in PWH and is associated with a severe prognosis at a relatively young age. Further studies are needed to identify risk factors associated with pancreatic cancer development in people with HIV.
Published Version
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