Abstract
An efficient method involving a Pd/PCy3 catalyst in combination with a stoichiometric amount of Ag2CO3 has been established for the decarboxylative CH bond arylation of thiophenes to give 2-arylthiophenes (see scheme; Cy=cyclohexyl). Electron-rich, electron-deficient, and heterocyclic benzoic acids can be used as the arylating reagent and a broad range of substituents on the thiophene are tolerated.
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