Abstract
However, a highly enantioselective Mannich reaction of α- cyanoketones with simple imines remains elusive; although, if successfully promoted with a practically accessible chiral catalyst under air- and moisture-tolerant conditions, it could provide a highly attractive, convergent approach toward optically active β-amino nitriles. As part of research program related to the development of synthetic methods for the enantioselective construction of stereogenic carbon centers,
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