Enantioselective Conjugate Addition of Fluoromalonate to Nitroalkenes Catalyzed by Chiral Nickel Complexes

Abstract

However, a highly enantioselective conjugate addtion of fluoromalonates to nitroalkenes remains elusive; although, if successfully promoted with a practically accessible chiral catalyst under air- and moisture-tolerant conditions, it could provide a highly attractive, convergent approach toward optically active γ-nitro fluoromalonates. As part of research program related to the development of synthetic methods for the enantioselective construction of stereogenic carbon centers,