Abstract
Objective To investigate the expression of paired basic amino acid cleaving enzyme 4 (PACE4) in prostate cancers and its clinical significance.Methods Expression of PACE4 was examined by immunohistochemistry in 72 cases of prostate cancer (PCa),20 cases of prostatic intraepithelial neoplasia(PIN) and 40 cases of benign prostatic hyperplasia (BPH).Results The positive rates of PACE4 in PCa,PIN and BPH were 92％,80％ and 20％ respectively,with a significant difference among them (P ＜ 0.05).Its accuracy rate and Youden index(95％ confidence interval) were 82％ and 60％ (45％-74％) respectively when diagnosing PCa and Non-PCa.A positive linear trend was found between PACE4 expression and clinical stage,preoperative serum prostate specific antigen (PSA) level,Gleason score and estimated-risk.Conclusion PACE4 expression in prostate tissue could well differentiate PCa from PIN & BPH,and could represent the prognostic risk appropriately. Key words: Paired basic amino acid cleaving enzyme 4; Prostate cancer; Diagnosis; Risk grade
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
