Features of serum PSA in HGPIN patients and the influencce of HGPIN positive needle biopsy unmber on the detection rate of PCa

Abstract

Objectives To study features of serum prostate specific antigen (PSA) characteristics in high grade prostatic intraepithelial neoplasia (HGPIN) and the first needle biopsy HGPIN positive number on prostate cancer (PCa) detection rate. Methods 551 patients with suspected PCa were diagnosed by biopsy. According to the diagnostic results, the detection rate of PCa was compared between the serum PSA level of each group and the HGPIN positive needle array in the first time. Results Biopsy results showed that 37.0% (204/551) of patients were PCa, 43.6% (240/551) of patients were benign prostatic hyperplasia (BPH) and 10.7% (59/551) of patients were low grade prostatic intraepithelial neoplasia (LG PIN). In those 48 cases of HG PIN patients, 28 cases were one positive needle, 13 cases were two positive needles, 7 cases were three or more positive neddles. Patients with PCa, two or more positive needles had significantly higher PSA level(P<0.05). The return visit of PCa detection rate were 12.8%(6/47) in BHP patients. In LG PIN were 10.3% (3/29), unifocal HGPIN patients were 10.7% (3 / 28), bifocal HGPIN patients were 23.1% (3 / 13), trifocal and above HGPIN patients were 57.1% (4 / 7). Conclusions The level of serum PSA in unifocal HG PIN patients is low, and the level of PSA in the multi focal HGPIN is increased, and the detection rate of PCa is increased during the multiple HGPIN biopsy. Key words: Prostatic Neoplasms; Prostate-Specific Antigen; Biopsy, Needle