Abstract
No abstract available.
Highlights
At present there is no method of reliably matching the amount of drug delivered with the surgical stimulus so we have to rely on mathematical models of pharmacokinetics to determine how to give an anaesthetic hoping this is adequate for the procedure
We assume the amount of drug present at the receptor is proportional to the effect that is produced by that drug. a
Pharmacokinetics attempts to produce mathematical models to explain the changes in concentration, decay and accumulation using the principles of absorption, distribution, metabolism and elimination
Summary
Any drug administered will have a gradual predictable decay in concentration while surgical stimuli do not follow this predictable time course. The major difficulty with anaesthesia is to accommodate these two totally different patterns to produce rapid induction, smooth maintenance and rapid emergence in concert with the varying degrees of stimuli and patient response. At present there is no method of reliably matching the amount of drug delivered with the surgical stimulus so we have to rely on mathematical models of pharmacokinetics to determine how to give an anaesthetic hoping this is adequate for the procedure
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