P796 Annual prevalence and clinical outcomes of ulcerative colitis with primary sclerosing cholangitis in Korea over the last 10 years

Abstract

Abstract Background The prevalence of ulcerative colitis (UC) in Korea has recently increased significantly, but there is few data for the prevalence and clinical outcomes of primary sclerosing cholangitis (PSC) associated UC. Thus, we assessed the prevalence of primary sclerosing cholangitis (PSC)and analysed clinical outcomes in Korean UC patients. Methods National Health Insurance System (NHIS) claim data from 2008 to 2017 were used in this population-based study. UC patients and PSC patients were identified by codes for ulcerative colitis (UC: K51) and (PSC: K830) in the NHIS registration system. Clinical events were defined as emergency department visit, hospitalisation, colectomy and liver transplantation. Results The overall number of UC with PSC & without PSC patients has increased steadily (Table 1). The prevalence of PSC in UC patients has increased since 2008 and was 0.33%in 2017.Clinical events were more frequent in UC with PSC, but the incidence of clinical events has decreased since 2008 in both groups (Figure 1).In 2017, the number of UC with PSC was 189 (male;118 vs. female;71) and the mean age of UC with PSC was 50.82 years(vs. UC without PSC;49.74). The incidence was low in teenagers and there was no difference in prevalence by age group. Conclusion This study confirmed that the prevalence of PSC is increasing in Korea. Additionally, UC with PSC patients have poor clinical outcomes. Therefore, the prevalence of PSC in UC patients suggests the need for greater attention and effort in clinical practice.