Abstract

Neurocircuit models of posttraumatic stress disorder (PTSD) point to ventromedial prefrontal cortex (VMPFC) hypoactivation, amygdala hyperreactivity, and hippocampus dysfunction. Non-invasive neuromodulation to boost VMPFC-assisted top-down inhibition of the amygdala in the context of exposure therapy might improve symptoms of PTSD. Here we report data on individual differences in 1) changes in psychophysiological arousal in response to transcranial direct current stimulation (tDCS) targeting the VMPFC combined with virtual reality exposure for PTSD, and 2) tDCS-induced electrical field distributions in VMPFC, amygdala, and hippocampus.

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