Abstract
Increased hippocampal volume and gene expression following cognitive behavioral therapy in PTSD
Highlights
In a recent study in Biological Psychiatry, Levy-Gigi et al found that a 12 weekly 90mins cognitive behavioral therapy (CBT) treatment in individuals with posttraumatic stress disorder (PTSD) is associated with an increase in hippocampal volume and expression of glucocorticoid receptor genes, known as FKBP5 (Levy-Gigi et al, 2013)
Despite the positive effect of psychopharmacological and behavioral therapy in PTSD, it is not known whether CBT and psychopharmacological treatments are associated with dissociable effects on the brain and behavior
Prior studies show that there is a trend for a negative correlation between higher reexperiencing symptoms and hippocampal volume (Shucard et al, 2012), perhaps suggesting that re-experiencing symptoms are more ameliorated than other PTSD symptoms following CBT treatment
Summary
In a recent study in Biological Psychiatry, Levy-Gigi et al found that a 12 weekly 90mins cognitive behavioral therapy (CBT) treatment in individuals with posttraumatic stress disorder (PTSD) is associated with an increase in hippocampal volume and expression of glucocorticoid receptor genes, known as FKBP5 (Levy-Gigi et al, 2013). A commentary on Association among clinical response, hippocampal volume, and FKBP5 gene expression in individuals with posttraumatic stress disorder receiving cognitive behavioral therapy by Levy-Gigi, E., Szabo, C., Kelemen, O., and Keri, S.
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