P65-T COMPASS-31 results differ depending on the type of dysautonomia

Abstract

Background The aim of this study was to compare the results of the Composite Autonomic System Score 31 (COMPASS-31) questionnaire depending on the results of the head-up tilt-table test (HUTT). Methods We enrolled 575 consecutive patients referred for HUTT. Each participant completed the Croatian version of COMPASS-31 for a subjective evaluation of the autonomic symptoms and underwent HUTT. Patients with normal HUTT, but abnormal cardiovascular reflexes were excluded from the analysis (N = 210). Patients were then divided into 4 groups: normal HUTT (N = 197), vasovagal syncope (N = 84), postural orthostatic tachycardia syndrome (POTS) (N = 27) and orthostatic hypotension (OH) (N = 57). Results of COMPASS-31 were then compared between all four groups. Results Patients with normal HUTT had significantly higher results on COMPASS-31 compared to patients with syncope in vasomotor, secretomotor, gastrointestinal and bladder domains (0.512 vs 0.268, p = 0.025; 2.600 vs 1.633, p = 0.010; 4.573 vs 3.699, p = 0.024; and 1.105 vs 0.569, p = 0.001; respectively). In contrary, patients with normal HUTT had significantly lower results on COMPASS-31 compared to patients with POTS in orthostatic intolerance domain (14.010 vs 18.815, p = 0.028) and patients with OH in orthostatic intolerance, gastrointestinal, bladder and total COMPASS-31 score (14.010 vs 17.684, p = 0.016; 4.573 vs 5.780, p = 0.028; 1.105 vs 2.164, p Conclusion COMPASS-31 exhibits different results depending on the various types of ANS dysfunction and may serve as a screening tool for various disorders that affect ANS.