P622 Health care consumption and treatment of Crohn's disease in Stockholm County

Abstract

conducted using chi-square test for categorical variables. P value <0.05 was considered for statistical significance. Results: In our study group there were 157 patients with elderly onset IBD (14.7%), with similar sex distribution as in non-elderly IBD patients. There were significantly less active smokers among elderly-onset IBD patients (5.9% vs 18.3%, p = 0.0007) and patients resided rural areas more frequently (33.8% vs 25.4% p = 0.02). Ulcerative colitis (UC) is more frequently encountered in elderly IBD patients (67.1% vs 57.5% p = 0.02). Colonic Crohn’s Disease (CD) L2 is more prevalent in our elderly cohort (61.2% vs 39.1% p = 0.003) whereas extensive ileocolonic CD (L3) was less frequent (24.5% vs 41.4%, p = 0.02). No significant association with extent of colonic involvement for elderly UC patients was identified. Malignization occurred 6 times more frequently in elderly IBD patients (1.9% vs 0.3% p = 0.01). With regard to therapeutic management, a significantly higher number of elderly-onset patients were treated with 5ASA (77.6% vs 49.9% p = 0.0002) whereas no significant differences were identified for corticosteroids or azathioprine treatments. There was no difference with regard to severity of disease flare in elderly vs. non-elderly IBD patients. Conclusions: In Romania elderly IBD patients have distinct epidemiological and phenotypical characteristics: higher frequency of UC and colonic CD phenotype and higher risk of malignization that requires active surveillance.