P55-10 A case of peritoneal mesothelioma that recurred 27 years later

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Peritoneal mesothelioma is one of the rare cancers for no effective treatment has been developed. This time, the patient was diagnosed with fallopian tube cancer at the first onset and did surgery and chemotherapy, but 27 years later, she had abdominal mass, peritoneal mesothelioma and ascites. We report including a review of the literature. A 64-year-old woman. No medical history. Onset in X-27 with a right abdominal mass. A diagnosis was right fallopian tube tumor, and laparotomy and total hysterectomy were performed. Pathological diagnosis was low to moderately differentiated adenocarcinoma. Five courses of CEP therapy were performed, and then with remission in X-27. In year X, she had a right abdominal mass, peritoneal dissemination, and ascites. Diagnosis of moderately differentiated adenocarcinoma by biopsy. Six courses of TC (+ BV) therapy were performed, and a remission was obtained on CT. Year X biopsy added immunostaining to diagnose mesothelioma. Reexamination of histopathological specimens from X-27, immunostaining could not be added, but HE staining did not show proliferation of epithelial cells. The main tumor was the mesothelium, which was re-diagnosed as mesothelioma. The tissue specimens of X-27 and X were very similar. Unlike peritoneal cancer, peritoneal mesothelioma is a malignant tumor derived from mesothelial cells and is a rare cancer, and difficult to treatment. The effects of surgery and radiation therapy are limited. CDDP + PEM therapy is often selected as the drug therapy according to pleural mesothelioma, but there is currently no treatment indicated or approved for. This time, we experienced a case in which both initial and recurrence were effective by ovarian cancer regimen, and we believe that it could be considered as one of the active treatments for peritoneal mesothelioma.