Abstract
p53 Protein Isoforms: Key Regulators in the Front Line of Pathogen Infections?
Highlights
Bacterial and viral infections represent a major type of cellular stress, triggering different biological countermeasures, notably mediated by the p53 pathway
D133p53a acts as a modulator of full-length p53 in response to stress, inhibiting p53-mediated apoptosis and G1 cell cycle arrest without inhibiting p53-mediated G2 cell cycle arrest
Three pioneer reports, including ours, have recently highlighted the role of p53 isoforms in epithelial cells infected by different pathogens: a gram-negative bacterium (Helicobacter pylori), a RNA, and a DNA virus [19,20,21]
Summary
Bacterial and viral infections represent a major type of cellular stress, triggering different biological countermeasures, notably mediated by the p53 pathway. P53b has been shown to modulate p53 transcriptional activity in a promoter-dependent manner [13]. Several studies report on the suppressive function of p53 isoforms and related deregulation of their expression in human cancers [18], investigations into the putative role of p53 isoforms and their regulation in pathogen infections have only recently begun.
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