Abstract
p53 and aging: role of p66Shc
Highlights
The p53 protein was discovered many years ago as a tumour suppressor gene and despite the wealth of information that has accumulated, a complete understanding of how p53 functions remains still elusive
Emerging findings suggest that p53 activity on specific target is regulated by specific p53 isoforms, in the context of specific activating-signals [3]
Recent studies have demonstrated the presence of internal ribosome entry site (IRES) sequences in p53 mRNA that mediated the translation of both full-length and p44/p53 isoforms and represent a novel control of p53 gene expression and activity [6]
Summary
The p53 protein was discovered many years ago as a tumour suppressor gene and despite the wealth of information that has accumulated, a complete understanding of how p53 functions remains still elusive. P53 is a key regulator of the checkpoint response to DNA damage in mammal cells and is affected by lossof-function mutations in the majority of human cancer. In response to stress signals p53 mainly acts to repair DNA damage and depending on the severity of the damage, the cell microenvironment and the cell type, p53 can orchestrate different cellular outcomes such as apoptosis and senescence.
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