P53 Contributes to the Chemotherapeutic Drug Doxorubicin-Induced Cell Death in Colorectal Cancer Cell Line HCT116

Abstract

Doxorubicin is a commonly used chemotherapy drug for cancer treatment, although its effectiveness varies across different cancer types. p53 is a key factor involved in cell death induced by therapeutic agents, and it can be upregulated by doxorubicin, exhibiting a function of apoptosis. To further investigate the mechanism between p53 and doxorubicin, this study explored whether p53 plays a role in doxorubicin-induced cell death in the colorectal cancer line HCT116. The findings revealed that p53 was upregulated in HCT116 cells when treated with doxorubicin, and the knockdown of p53 decreased the sensitivity of HCT116 cells to doxorubicin. These results suggest that p53 plays an important role in doxorubicin-induced cell death in HCT116 cells, potentially contributing to more effective treatment approaches.