P486. Cross-Hemispheric Gamma Synchrony in Prefrontal PVI and Subpopulations of Projection Neurons are Modulated Differentially in a Task-Dependent Manner

Abstract

Neural networks in the prefrontal cortex (PFC) are responsible for several cognitive processes known to be disrupted in conditions such as schizophrenia. These networks, which are organized by both local microcircuits and inter-regional projections, require precisely tuned neuronal activity to generate appropriate cognitive responses. One way these networks achieve this precision is through synchronization of neural oscillations which may entrain relevant neurons and/or reduce the activity of irrelevant neurons. Gamma-frequency oscillations in particular have been shown to play an important role in prefrontal-dependent cognition.