P41.05: Prediction of pre‐eclampsia using a combination of first trimester arterial pulse wave analysis and second trimester uterine artery Doppler waveform

Abstract

Results: The resistance index in the pre-term pre-eclampsia group (mean = 0.7) was significantly higher (P < 0.0001) compared to the control group (mean = 0.54) as well as compared to the term pre-eclampsia group (P < 0.0001). In the term pre-eclampsia group, the resistance index (mean = 0.56) was just significantly higher compared to the controls (mean = 0.54, P = 0.02). ROC curves generated also showed that uterine artery Doppler had a very good sensitivity for predicting pre-term pre-eclampsia. The ROC data showed that uterine artery Doppler is not sensitive at all for predicting term pre-eclampsia (r2 = 0.99). Conclusion: These data showed that uterine artery Doppler had a good sensitivity for pre-term pre-eclampsia, but was not of value in predicting term pre-eclampsia. As uterine artery Doppler changes are known to reflect spiral artery transformation by the developing trophoblast, it is possible that defective transformation of spiral arteries is not a predisposing factor for term pre-eclampsia.