171. Association between adverse maternal clinical outcomes and imbalance of cytokines and angiogenic factors in preterm preeclampsia

Abstract

Introduction Preeclampsia (PE) is a pregnancy specific syndrome, characterized by abnormal levels of cytokines and angiogenic factors, suggesting that immunological factors play a role in the disease development. Objective The objective of this study was to determine whether immunological markers are associated with the gestational age and with the disease severity at the time of the disease diagnosis. Methods Ninety-five women who developed PE were stratified for gestational age as preterm PE ( α ) and Interleukin 10 (IL-10) were determined by immunoenzymatic assay (ELISA). Results were analyzed by non-parametric test with significance set at p Results The comparison between preterm and term PE showed higher percentage of severe cases in the preterm PE (76.7%) than in the term PE (23.3%) group. Similarly the concentrations of TNF- α , TNF- α /IL-10 ratio, sFlt-1, sEng and sFlt-1/PlGF ratio were significantly higher in the preterm PE group. On the other hand, concentrations of PlGF, VEGF and IL-10 were significantly lower in the preterm PE group. Negative correlations between TNF- α and IL-10 (r = −0.5232; p Discussion Pregnant women with preterm PE showed an imbalance between immunological markers, with predominance of anti-angiogenic factors and TNF- α , associated with adverse maternal clinical outcomes.