P4.08 - Expression of Epidermal Growth Factor Receptor in Human Endometrial Hyperplasia and Carcinoma

Abstract

ABSTRACT According to researches, there are many discordant data about the prognostic significance of epidermal growth factor receptor in endometrium. The intensity of Epidermal Growth Factor Receptor (EGFR) expression in human endometrial hyperplasia and carcinoma was the focus of our study. 45 patients have been investigated clinically and morphologically. Of them, 27 patients of reproductive age, 8 patients of gestational age and 10 patients of postmenopausal period. Clinical examination revealed endometrial hyperplasia manifested by metrorrhagia in 35 (27 + 8) patients. For morphological study the material was collected by endometrial scrap. Histological and immunohistochemical studies were performed as well. The numeric data obtained were processed statistically using the SPSS-12 program. Based on the results, expression of epidermal growth factor receptor was diagnosed in 100% of the patients. Of them, mild EGFR expression was documented in 42.2% (p 0.1). In complex endometrial hyperplasia with atypia (only one case of atypical hyperplasia), EGFR was revealed with high intensity. The results of the study suggest that in complex hyperplasia mild EGFR expression predominates, while sharp EGFR expression is mostly typical of complex hyperplasia. At the same time, EGFR staining intensity increases with the severity of hyperplasia. With endometrial carcinoma (endometrioid carcinoma, adenocarcinoma), a drastic intensity of EGFR expression is observed.