Abstract
In addition to the association between obesity and cardiovascular disorders, with the presence of a vascular burden as a cofactor, recent studies have particularly focused on the association between indicators of obesity and dementia. A high BMI can increase the risk for dementia when measured before clinical dementia onset. Although the use of BMI in population-based and clinical studies is feasible, this is an index of obesity and shows limits in its ability to distinguish between fat and fat-free mass or between visceral and subcutaneous abdominal fat. Subjects were followed up for about 2 years; 433 persons had BMI data and body fat distribution data by abdominal fat CT analysis. Cognitive function was ascertained using standard methods including K-MMSE and CERAD-K. Cognitive dysfunction was analyzed using follow-up as time to event, adjusting for demographics and apolipoprotein E-epsilon4 status. Compared with subjects in the first quartile of initial BMI, subjects in the third quartile had a lower cognitive dysfunction. For total abdominal fat amount, subjects in the second quartile had a lower cognitive dysfunction. The association between adiposity and cognitive dysfunction resembled a U shape in the elderly Korean. The prospective association between adiposity and cognitive dysfunction differs depending on the body fat distribution. This may explain previous conflicting reports. Larger prospective studies are required to investigate this further.
Published Version
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