Abstract
Airborne particulate matter causes oxidative damage, inflammation, and premature skin aging. The purpose of this study was to examine the anti-inflammatory and anti-oxidative effects of resveratrol and resveratryl triacetate (RTA) against particulate matter PM10. Primary human epidermal keratinocytes were exposed in vitro to PM10 in the absence or presence of resveratrol and RTA. Assays were performed to determine cell viability, production of reactive oxygen species (ROS), and expression of pro-inflammatory cytokines. PM10 treatment (3~100 g mL−1) decreased cell viability and increased ROS production and the expression of pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-1f3 (IL-1f3), interleukin-6 (IL-6) and interleukin-8 (IL-8). Resveratrol and RTA at 1~10 M reduced cytotoxicity and ROS production due to PM10. Also, the PM10-induced expression of pro-inflammatory cytokines was attenuated by resveratrol and RTA. This study suggests that resveratrol and RTA can rescue keratinocyte viability and attenuate the inflammatory responses of these cells due to airborne particles.
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