P3-05-09: Comparison of Clinical Features and Patterns of Recurrence in Triple Negative Breast Cancers in Relation to Other Breast Cancers.

Abstract

Abstract Background : Breast cancer is an heterogeneous disease that have several and different biological characteristics and clinical behaviours. Of these, triple negative breast cancer represents 10–17%.This kind of tumor is characterized by estrogen, progesterone and HER2 receptor negativity and they are very aggressive, associated with poor prognosis, younger patients, high incidence of metastases and shorter relapse free survival. Triple negative breast tumours are more likely to experience local recurrence and distant relapse than other breast tumors, and require a more aggressive intervention. PURPOSE : To compare the incidence of metastases, clinical features and outcome among patients with triple negative breast cancer and women with other types of breast cancer. METHODS : This is a retrospective cohort analysis from 3893 patients with invasive breast cancer, diagnosed between January 2000 and April 2011 and attended at Brazilian Institute of Cancer Control (IBCC) in Sao Paulo, Brazil. Five hundred of these tumors were triple negative. We made a correlation of clinical variables such as age, tumor stage (TNM) and analysis of last follow-ups, such as metastases, disease free survival, death for tumor, death for other reasons, lost of follow-up, hygiene and diet regime (RHD) and local recurrence. Results: The median follow-up for the cohort was 4,29 years. The mean age at diagnosis in triple negative group was 54,8 and for the others group was 57,1 years. Subgroup analysis of tumor grade showed that the triple negative breast tumors were diagnosed later (Stage II and III; p:<0,0001). There was no difference in the appearance of the two types of tumors, when considering diagnose age. The incidence of metastases, death for tumor and free survival in triple negative tumors, respectively; 25,6%, 13,8% and 57,2% (p:<0,0001) demonstrates the aggressiveness of this kind of tumor. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P3-05-09.