P27 Prognostic Value of Lymph Node Ratio N2 Non–Small Cell Lung Cancer Fulfilling NCCN Resection Criteria

Abstract

The aim of the study was to evaluate the prognostic value of lymph node ratio in N2 non–small cell lung cancer fulfilling NCCN resection criteria. 203 cases of pathological N2 non–small cell lung cancer patients were enrolled who received radical resection fulfilling NCCN resection criteria at the department of Thoracic Surgery II, Peking University Cancer Hospital from January 2006 to December 2014. The univariate analysis between clinicopathological variables and prognosis used log-rank. Cox regression was conducted to identify the independent prognosis factors for N2 non–small cell lung cancer. The 5 year over survival was 44.8%. Age, gender, pathology, T stage, viscerl pleural invasion and single N2 metastasis were not correlated with the prognosis. Tumor size (P=0.030), skip N2 metastasis (P=0.009), single station N2 metastasis (P=0.01) and lymph node ratio (P<0.001) significantly impacted N2 Non–small cell lung cancer prognosis. Cox regression analysis confirmed that tumor size (P=0.017) and lymph node ratio (P=0.010) were the independent prognosis factors. The 5 year over survival was 70.1% for the low risk group with tumor size less than 3cm and lymph node ratio less than 0.19. However, the 5 year over survival of high risk group with tumor size more than 3cm and lymph node ratio more than 0.19 was 24.5%, which was significantly different with the low risk group(P<0.001). Lymph node ratio and tumor size were the independent prognosis factors for N2 Non–small cell lung cancer fulfilling NCCN resection criteria, the risking groups based on lymph node ratio and tumor size can be better to predict the prognosis of N2 non–small cell lung cancer.